does semaglutide affect sperm Everyone's talking about GLP1's, like Ozempic and Wegovy, for weight loss. But almost nobody is talking about: What do GLP-1 medications mean for male fertility? The truth is we still don't have GLP-1 Medications and Male Fertility:

By your follow-up appointment, you're left with vague impressions rather than facts about when symptoms began, how often they occur, or whether they're improving

Effectiveness Comparison When it comes to semaglutide vs tirzepatide effectiveness, the clinical trial results are staggering: Semaglutide Results Average weight loss: 15-17% of body weight 83% of patients lost at least 5% of their weight 66% lost at least 10% of their weight 48% achieved 15% or greater weight loss Tirzepatide Results Average weight loss: 16-22% of body weight 91% of patients lost at least 5% of their weight 83% lost at least 10% of their weight 57% achieved 20% or greater weight loss To put this in perspective, if you weigh 200 pounds, semaglutide could help you lose 30-34 pounds on average, while tirzepatide could help you lose 32-44 pounds

Experimental observations suggest the compound may be relevant in investigations related to energy balance and mass regulation processes in research preclinical models

Last reviewed: April 2026

That said, both medications can cause gastrointestinal side effects like nausea, so you may notice these are more pronounced when starting Wegovy while already on sertraline